Toxic Barrel

⭐ RARE ITEM

Effect: When you take damage, Toxic Barrel releases a lingering poison cloud that damages and poisons nearby enemies.

Early tip

New to poison builds? Start by browsing the Items index to unlock a few low-risk sustain pieces before centering a build on Toxic Barrel.

Rarity

Rare

Trigger

When you take damage

Unlock

2,000 poison kills

Playstyle

Poison AoE / Area denial

🧪 How Toxic Barrel Works

Toxic Barrel converts your moments of vulnerability into offense: every time you take damage, it emits a toxic cloud that lingers and applies poison. This naturally complements close-range brawling, kiting choke points, and any setup that keeps enemies around you.

✓ Advantages

Reliable poison application without extra button presses
Excellent crowd control and area denial in corridors
Stacks well with other poison amplifiers

✗ Disadvantages

Requires you to be hit—plan sustain accordingly
Less value in pure ranged kiting with zero contact

🔓 How to Unlock Toxic Barrel

Requirement

Kill 2,000 enemies using Poison damage across your runs. Poison sources include items and weapons such as Poison Flask.

Use poison-centric weapons (e.g., Poison Flask) to accelerate progress.
On crowded maps, drag mobs through your poison zones to maximize ticks.
Track progress between runs; you don’t need to finish in a single attempt.

🔗 Best Synergies & Build Notes

Moldy Gloves

Poison-focused item that amplifies damage-over-time gameplay. Barrel supplies frequent poisoning; Gloves scale it further.

Poison Flask (weapon)

Directly applies poison from range. Combines with Barrel’s on-hit cloud to saturate the arena with DoT.

Gas Mask

Defensive pairing for poison builds. Multiple reputable guides describe Armor plus a sustain interaction tied to poisoned enemies. Treat it as your survivability anchor in melee-leaning poison setups.

Playstyle Tips

Fight near corners and choke points so the lingering cloud hits waves sequentially.
Pick up at least one sustain tool (regen/lifesteal/overheal interaction) before facetanking.

🖼️ Poison Build Visual

Poison Flask weapon art — Poison Flask pairs naturally with Toxic Barrel in DoT-focused runs.

📋 Patch & Balance Context

As of Patch v1.0.12 (Oct 8, 2025), no official notes specifically change Toxic Barrel. The patch largely reworked late-game swarms and adjusted meta outliers; poison play remains viable with proper sustain.